I had a 21 day progesterone labs done March 21st which confirmed negative for ovulation. My period in April was late so I again had labs done to confirm negative pregnancy on April 5 and started Provera on April 8th 10mg X7 days. Before taking this medicine. Provera can cause birth defects. Do not use if this medicine you are pregnant. Tell your doctor right away if you become pregnant during treatment. Can medroxyprogesterone cause miscarriage. Common Questions and Answers about Can medroxyprogesterone cause miscarriage. depo-provera. It is not safe if taken during early pregnancy. It can cause minor birth defects if taken in the first trimester. Do discuss all your concerns with your doctor. Do keep us posted. Take care and regards! Read More. I was told the first period after a. I was on Depo Provera for about 8 years when my husband and I decided to try for another baby. I received my last injection in September 2006. Provera does not cause miscarriage, but some studies have shown that there may be a link between certain birth defects in mothers who are exposed to progestins such as Provera during the first. My mother took Provera to prevent miscarriage in in 1974. I was born with a club foot on my left side. I found out in my 30's that I am missing my left kidney, ovary, and the left side of my uterus is underdeveloped. I did have a daughter nine years ago, but delivered c-section b/c she was breech. I don't think you'll have a miscarriage if you are taking Provera while you are pregnant. but it can certainly have negative effects on the baby. Provera will not cause you to have a miscarriage. People should follow up on information before staring it. People should follow up on information before staring it. Provera is perfectly safe for use during pregnancy. On one hand, too-low levels could theoretically cause miscarriage if the uterus is not ready to support a pregnancy, perhaps because the ovaries have problems producing enough progesterone for some reason. What pills cause miscarriage at 3 weeks pregnant and how many ibuprofens does it take to cause a miscarriage? To have an abortion at 3 weeks you go to a doctor and get either the medical abortion.